5 Reasons People Are Ditching Ordinary B Complex for Tri-Methyl+
Most B complexes use synthetic forms your body still has to convert. If you carry an MTHFR
variant, that conversion may not happen efficiently — which is why so many people take a B
complex for months and feel nothing. Tri-Methyl+ delivers both active forms of B12,
methylfolate, and the full B spectrum in one capsule a day.
★★★★★1,200+ 5-star reviews across Athelas NeutraceuticalsMade in the USAShips same day
60 capsules · one a day · 2-month bottle
“It's hard to find Methyl B vitamins. Regular B complexes made me feel terrible, so I avoided
taking them. A functional medicine doctor directed me to take the methyl type — and wow, what
a difference.”
T · Verified purchase ★★★★★
Why the switch
Five things ordinary B complex gets wrong
Each one is a step in the same chain. Miss any of them and the rest matter less.
01
The B12
Two active forms of B12. Most supplements give you one.
Open almost any B complex and you'll find cyanocobalamin — the cheapest form, and the one
your body has to convert before it can do anything. Tri-Methyl+ uses
methylcobalamin and adenosylcobalamin, the two forms that actually occur
in the human body. Your cells use them as-is.
Methylcobalamin works in the bloodstream and nervous system. Adenosylcobalamin works
inside the mitochondria, where energy is produced. Most "methyl" B complexes include only
the first one.
What's actually in the capsule
Typical B complex
B12CyanocobalaminSynthetic. Must be converted first.
One form. One job — if the conversion happens.
Tri-Methyl+
B12MethylcobalaminBlood & nervous system
B12AdenosylcobalaminMitochondria — where energy is made
Both natural forms. Ready to use as-is.
Most "methyl" B complexes stop at methylcobalamin. The adenosyl form is the one
that goes to work inside your mitochondria.
What's on the label
Typical B complex
Tri-Methyl+
Form of B12
Cyanocobalamin
Methyl + adenosyl B12
Form of folate
Folic acid
Methylfolate (5-MTHF)
Form of B6
Pyridoxine HCl, high dose
Includes P-5-P, 10 mg
Conversion required
Yes
No — already active
Flow agents & fillers
Stearates, silicon dioxide
None
Capsules per day
1–3
1
02
The folate
Methylfolate, not folic acid
Folic acid is synthetic. Before your body can use it, it has to be converted — and the
MTHFR gene variant that makes that conversion inefficient is common enough that a lot of
people are quietly taking a folate they can't fully use.
Tri-Methyl+ skips the step entirely with 5-MTHF, the active form of folate,
paired with both active B12s. Together they support the methylation pathway — the process
behind DNA repair, mood regulation, detoxification, and cellular energy.
The conversion step — and how to skip it
Folic acid (most B complexes)
Folic acidSynthetic
→
MTHFR enzymeBottleneck
→
5-MTHFIf conversion works
→
Your cellsMaybe
Methylfolate (Tri-Methyl+)
5-MTHFAlready active
→
Your cellsDirectly
A common MTHFR variant slows the middle step. Starting with 5-MTHF means there
is no middle step to slow down.
It's the single most common reason customers tell us they came looking for us.
03
The dose
B6 as P-5-P — at a dose that makes sense
More is not better with B6. Plenty of products load up on it to make the label look
impressive, and people sensitive to high amounts feel it.
We use Pyridoxal-5-Phosphate — the active coenzyme form — at a deliberately low,
balanced dose. You get the benefit of B6 in the form your body uses directly,
without the megadose. Every nutrient in the formula is there in ratio to the others, not
in whatever amount looks best on a panel.
Vitamin B6 per serving
Many B complexes50–100 mg
Tri-Methyl+10 mg, including P-5-P
A bigger number on the label isn't a better formula. Ratio between nutrients
is what we optimised for — 10 mg is a maintenance dose, not a megadose.
04
The spectrum
The whole B family, plus choline. One capsule.
A methyl B12 on its own leaves gaps. Tri-Methyl+ covers the full spectrum — including
choline for neurotransmitter synthesis and memory, and
biotin for hair, skin, and nails — so you're not stacking three products
to get complete coverage.
Methylcobalamin
Adenosylcobalamin
Methylfolate (5-MTHF)
B6 as P-5-P
Thiamine (B1)
Riboflavin (B2)
Niacin (B3)
Biotin (B7)
Choline
One capsule a day, taken with breakfast or alongside your multivitamin. That's the routine.
Everything on the panel, in one capsule per day.
05
The source
Made and shipped direct. Nothing sitting on a shelf.
We manufacture the product and ship it to you from our own facility — no regional
warehouses, no months on a big-box shelf under fluorescent lights. Every batch is produced
under strict quality controls in a GMP facility in the USA.
It also means the price isn't padded by three layers of distribution, which is how a
formula built on active, more expensive ingredients still lands at
$24.50 a bottle.
How the bottle reaches you
The usual route
Contract plant
→
Regional warehouse
→
Distributor
→
Retail shelfWeeks to months
→
You
Ours
Our GMP facilityMade to order
→
YouShips today
Fewer stops means a fresher capsule — and a price that isn't carrying three
markups.
Most capsules carry flow agents and anti-caking powders that exist to make manufacturing
faster — not to do anything for you. We reformulated to remove them.
✕No magnesium stearate
A lubricant that keeps machinery from jamming. It isn't a nutrient.
✕No silicon dioxide
An anti-caking agent added to keep powder free-flowing on the line.
Same complete methylated formula — both active forms of B12, methylfolate, and low-dose
B6 as P-5-P — in a vegetable capsule, one a day.
Your discount is applied at checkout
Ready to feel what active B vitamins do?
A full 60-capsule bottle — both active forms of B12, methylfolate, and the complete B
spectrum — for 58% off, with free shipping.
🛡️ 30-day satisfaction guarantee. If Tri-Methyl+ isn't right for you, contact
us within 30 days for a full refund. No questions asked.
Unedited customer reviews
What people say after a few weeks
4.7
★★★★★
37 reviews for this product
5 star76%
4 star19%
3 star5%
★★★★★✓ Verified purchase
Lower B6 for people over 50
So far this is working for me. I like the lower mg of B6 and that is why I purchased it. I open the capsule and drink it with water. Definitely an energy booster for me, and good for the scalp as well.
★★★★★✓ Verified purchase
Better B vitamins
These Vit B complex is much easier to absorb & it smells better, too! It doesn't cause urinary discomfort as much, either. They were recommended by my cardiologist.
★★★★★✓ Verified purchase
Good ratio
This was the second time I purchased this product. The strength of each vitamin is good — not too much, not too little. I like the fact that it has methylated vitamins. I took a star off for the price. I wish it weren't so expensive.
★★★★★✓ Verified purchase
Very effective
Every time I take these my body just loves it, and makes my hair grow where I can feel it crawling out my scalp. My body loves what this is serving.
★★★★★✓ Verified purchase
Works well
Wife said it works.
★★★★★✓ Verified purchase
These helped me
I've been using these for a few weeks and have already noticed a change in brain fog, always tired, and more.
★★★★★✓ Verified purchase
Works great
Works as good as the shots.
★★★★★✓ Verified purchase
Great option for those with MTHFR
This vitamin B supplement is formulated for those with the MTHFR gene mutation that doesn't allow the proper absorption of B vitamins. This mutation leads to fatigue and a host of other symptoms from improper metabolism of the B vitamins. Methylated vitamins are required for proper absorption.
★★★★★✓ Verified purchase
MTHFR gene
Love this! I have the MTHFR gene and this stays in stock at my home.
★★★★★✓ Verified purchase
The power you don't notice
This product is highly effective and no side effects. The fact I don't feel it means it's working, and gives an overall feeling of well-being.
★★★★★✓ Verified purchase
Outstanding product
Finally a B complex that works for my MTHFR!
★★★★★✓ Verified purchase
Gives me wings!
Love it! Gives me energy during the day. It will cause you to go to the bathroom, because that's what vitamin B will do. Does what it says it will do.
★★★★★✓ Verified purchase
Tri-Methyl+ B Complex
So far, no complaints!
★★★★★✓ Verified purchase
As described
As described.
★★★★★✓ Verified purchase
Haven't noticed a visible effect
Unfortunately I didn't see any difference in my health or wellbeing after taking these vitamins consistently.
★★★★★Free product review
Higher quality vitamin B complex
This supplement contains both naturally occurring forms of vitamin B12: methylcobalamin and adenosylcobalamin. Naturally occurring B12 has the advantage of better and longer retention after absorption. Adenosylcobalamin is particularly important to supporting and protecting the mitochondria in your cells — they are like power plants in each cell, and adenosylcobalamin helps them create energy more efficiently.
Folate 5-MTHF bypasses the entire folate metabolization and is directly absorbed to exert the biological activity. Therefore 5-MTHF is considered superior to folic acid.
Made in the USA in a GMP certified facility. The capsules are easy to swallow and don't have a bad taste.
★★★★★Free product review
Great quality ingredients, 60 servings
Excellent full spectrum B-complex supplement, using the active (most bioavailable) forms, and the serving size is just one daily. I couldn't notice any taste. So far these agree perfectly with no side effects, and I do feel like these give me some more energy.
The vitamin B12 (700 mcg) uses two high quality active forms — adenosylcobalamin and methylcobalamin — and also includes B1 (25 mg), B2 (25 mg), niacin (15 mg), B6 (10 mg), biotin (300 mcg), folate (400 mcg), pantothenic acid (100 mg), choline (50 mg), pantethine (25 mg) and inositol (50 mg).
Overall I highly recommend. GMP facility, naturally sourced, 60 servings. Manufactured in the USA.
★★★★★Free product review
Finally, relief from the fatigue!
A friend clued me into this Tri-Methyl stuff that is supposed to help those of us who do not process B12 the way normal people do. I get tired instead of feeling more energy. I'm now in menopause and the fatigue can be overwhelming most days.
I'm telling you, I don't know what magic potion this stuff is, but in only 4 days I can already feel the difference. I thought day one was a fluke. But then day two, and day three. This is very unusual for me — one good day of energy usually requires a week of recovery, and this is the only thing I've done different. I feel good, feel positive, have energy. Even a few aches and pains I normally have all day long don't seem to bother me as much. I actually look forward to taking this after breakfast.
★★★★★Free product review
Love the natural energy boost
This supplement contains B12 methylcobalamin, adenosylcobalamin, methylfolate, as well as B1 thiamine, B2 riboflavin, niacin, B6 as P-5-P, biotin, choline and more. I love that they give me a nice, natural energy boost to get going in the morning. I feel like they help fill in the gaps in vitamins.
The recommended dose is just 1 capsule a day, and each 60ct bottle is a 2-month supply, which makes them a good value. They are odorless and flavorless. I can take the capsule on an empty stomach before I head to work and not experience any negative side effects, which is great.
★★★★★Free product review
Great full-spectrum B vitamin supplement
Riboflavin is needed to help the body change vitamin B6 and folate into forms it can use, and it's important for growth and red blood cell production. In addition to producing energy, riboflavin works as an antioxidant.
Biotin is involved in a wide range of metabolic processes, primarily related to the utilization of fats, carbohydrates and amino acids. Biotin deficiency can cause thinning of the hair.
This is a great formula with many other great vitamins, offering 60 servings, and it is produced in the USA at a GMP-certified facility.
★★★★★Free product review
High quality B complex supplement
This is an excellent vitamin B complex supplement. Many supplements are more or less bioavailable depending on the exact chemical form of the vitamin, and the better, more bioavailable forms are generally more costly. This B complex has the good stuff. It's manufactured in the USA in a GMP facility, and the bottle I received had a very long shelf life.
★★★★★Free product review
Mostly good
B vitamins are very important to my health due to a genetic issue. I take bioactive B12 and methylfolate every day. This product contains good maintenance doses for me.
I like that this product has methylfolate and two forms of active B12 — that's great. It has a wide range of other B's. My main complaint is with the B6: I would prefer the full 10 mg to be the active form.
I like that I just need to take 1 capsule for a dose. This complex did, for me, what good B vitamins do: I feel better, I have more energy, I think better.
★★★★★Free product review
Active form, one capsule dosage
This is a high quality B vitamin complex. The methylated form is much better absorbed by most. The capsules are easy to swallow and do not cause me any digestive upset. I feel more energetic when taking these! It's a great feeling to get a genuine and sustained boost rather than just ingesting more caffeine.
★★★★★Free product review
Solid B vitamin supplement
This B vitamin supplement covers all the B vitamins, which some others do not. I never knew there were so many until I read the label on this. There is one capsule to a dose, which makes this a 60 day supply. It is made in a GMP facility and in the USA, which is a huge bonus. Taking these I didn't get any bad side effects and generally felt better. Worth a try if you're in the market for a B supplement.
★★★★★Free product review
Most complete vitamin B
These pills are the most complete and easier to absorb form of vitamin Bs on the market. I used to get B12 shots every once in a while, but with these I don't feel I need to. Glad I found these.
★★★★★Free product review
Great source of active forms of B12
I have been on the lookout for a B vitamin that has the 2 active forms of B12 — methyl B12 and adenosyl. This one seems to be the B complex I'm looking for, and more.
★★★★★Free product review
Works great
It's hard to find methyl B vitamins. Regular B complexes made me feel terrible so I avoided taking them. A functional medicine doctor directed me to take the methyl type, and wow — what a difference!
★★★★★Free product review
Good B complex supplement
A comprehensive B complex supplement focused on methyl B12, adenosyl B12 and methylfolate. These all play crucial roles in a healthy brain, and in nerve and blood cell regeneration. We also get a metabolism boost from adenosyl, which allows us to generate energy more efficiently. It's a once-a-day supplement and comes with a 60 day supply.
★★★★★Free product review
Good blend
This is a good methyl-B supplement. I've tried a few different brands. This one is just as good as any of the others I've come across. If the dosage looks good to you, it should be a product that will serve you well.
★★★★★Free product review
Multiple forms of vitamin B, one capsule
These full spectrum vitamin B capsules are standard size, easy to swallow, and you only need to take one a day. They contain multiple forms of vitamin B that other supplements don't have, and I like that. This bottle contains 2 months worth and they seem to have high quality ingredients. They are also manufactured in the USA.
★★★★★Free product review
Good for MTHFR
One capsule a day, easy to swallow and take. It was packaged well, too.
★★★★★Free product review
Nice
My husband likes this vitamin B complex. He says it's easy to swallow and no weird aftertaste.
★★★★★Free product review
Good all-around B vitamin
Good all-around vitamin B. You only need to take one, so this pack will last for 2 months. No aftertaste and the capsule is not hard to swallow. I recommend this product.
★★★★★Free product review
Works well
Works well and seems to give me some extra energy. They do have a slight B vitamin smell (expected). Not too much of a taste. These seem to have almost the same effectiveness for me as a food-based B complex.
★★★★★Free product review
Perhaps a step up
I'm always on the lookout for better vitamins, mostly meaning more absorptive and available for use by the body. I find these capsules easy to swallow, and I like that the supplement facts recommend only one capsule per day as sufficient. Methylated vitamin B is a more complete form and more easily metabolized by the body, so I decided to give these a try.
★★★★★Free product review
They're big, but they go down easy
I've been using these for a few weeks now. They are big. It goes down easy enough with enough to drink. There is no weird taste to it, nor does it cause any weird burping. I'd get these again.
★★★★★Free product review
Methylated folate and B
This product combines methylated folate and B vitamins, potentially allowing those recommended to supplement for MTHFR support to take one capsule instead of individual doses. Could be a helpful alternative if the amount of each inclusion is comparable to what you normally take. I didn't notice any taste and had no issues swallowing. Didn't experience negative impacts.
Reviews marked “free product review” were written by customers who received the product at no
charge through the Amazon Vine program. They are published here unedited apart from trimming
for length.
Questions people ask first
What makes a "methylated" B complex different?
Methylated means the vitamins arrive in the form your body actually uses, rather than a
synthetic precursor it has to convert first. Tri-Methyl+ uses methylcobalamin and
adenosylcobalamin instead of cyanocobalamin, and methylfolate (5-MTHF) instead of folic
acid.
Do I need to know whether I have an MTHFR variant?
No. The formula is built on active forms, which work whether or not you carry a variant —
the difference is that people who do carry one tend to notice more, because the synthetic
forms were doing less for them to begin with. If you're unsure, your healthcare provider can
order the test.
How do I take it?
One capsule daily, with or without food. Most people take it in the morning with
breakfast. Each bottle contains 60 capsules — a two-month supply at one a day.
Why is the B6 dose low?
Because B6 is a nutrient where more isn't better, and some people are sensitive to high
amounts. We use the active P-5-P form at a level chosen to sit in proper ratio with the rest
of the formula.
How long until I notice anything?
It varies. Some customers report a difference within the first week; for others it's more
gradual and shows up as steadier energy over a month or two. That's part of why the 6-bottle
supply is the most popular option — and why every order is covered by the 30-day guarantee.
What's your return policy?
Contact us within 30 days for a full refund, no questions asked. We manufacture this
ourselves and stand behind every bottle.
Get the complete formula for 58% off
Both active forms of B12, methylfolate, B6 as P-5-P, and the full B spectrum with choline —
manufactured direct and shipped fresh, with free shipping and a 30-day guarantee.
★★★★★1,200+ 5-star reviews brand-wideShips same day30-day guarantee
* These statements have not been evaluated by the Food and Drug Administration. This product
is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.
Consult your healthcare provider before starting any new supplement regimen.
